Response to Letter Regarding Article, “Bypassing Big Pharma”

Bypassing big pharma.

There have been many resounding victories in the war against coronary artery disease. Among those are antiarrhythmic drugs, pacemakers, coronary bypass surgery, coronary angioplasty, reperfusion therapy, and statins. But the one goal that has continuously eluded us has been the clinical availability of an effective cardioprotective agent. Although reperfusion therapy has partially achieved the ...

Response to letter regarding article, "reducing sodium intake to prevent stroke: time for action, not hesitation".

Response to Letter Regarding Article "Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity".

BACKGROUND Cell fate is fluid and may be altered experimentally by the forced expression of master regulators mediating cell lineage. Such reprogramming has been achieved with the use of viral vectors encoding transcription factors. We recently discovered that the viral vectors are more than passive vehicles for transcription factors because they participate actively in the process of nuclear r...

Response to letter regarding article, "Relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation".

Response to Letter Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” We thank Dr Shang for his interest in our study. We assessed cerebral autoregulation based on the relation between fluctuations in arterial pressure and those in middle cerebral artery blood flow before and after pharmacological blockade of 3 proposed me...

Response to letter regarding article, "Neurological, functional, and cognitive stroke outcomes in Mexican Americans".

BACKGROUND AND PURPOSE Our objective was to compare neurological, functional, and cognitive stroke outcomes in Mexican Americans (MAs) and non-Hispanic whites using data from a population-based study. METHODS Ischemic strokes (2008-2012) were identified from the Brain Attack Surveillance in Corpus Christi (BASIC) Project. Data were collected from patient or proxy interviews (conducted at base...